Low Dose Naltexone (LDN)
Low Dose Naltrexone
Over the last few years we have started many patients on low dose naltrexone (LDN). Naltrexone is a drug that has been available for many years. Traditionally, this drug is indicated for the treatment of opiate dependence or addiction. However, when used at less than 1/10 the dose used for opiate dependence, it can stimulate the immune system to promote healthy cell growth. We have used it successfully for patients with fibromyalgia. Together with an anti-inflammatory diet, we have seen tremendous improvements in patient’s chronic pain.
How does low dose naltrexone work? Click here.
At low doses, naltrexone acts differently than at standard doses:
- Temporarily blocks opioid receptors → triggers the body to produce more natural endorphins
- Reduces microglial activation (calms overactive immune cells in the brain)
- Decreases pro-inflammatory cytokines
- Helps regulate immune system balance without broad immunosuppression
More information on low dose naltrexone available here: lowdosenaltrexone.org
Chronic Pain & Central Sensitization
- Fibromyalgia
- Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (ME/CFS)
- Migraines & Chronic Headaches
Autoimmune & Inflammatory Diseases
- Rheumatoid Arthritis (RA)
- Systemic Lupus Erythematosus (Lupus)
- Multiple Sclerosis (MS)
- Inflammatory Bowel Disease (Crohn’s & Ulcerative Colitis)
LDN is used off-label for these conditions. While research (including randomized trials and real-world studies) shows promising results for pain reduction, fatigue, and quality of life in many patients, individual responses vary. It is typically used as part of a comprehensive treatment plan.
What to Expect During Your Consultation
- Comprehensive review of your medical history and current symptoms
- Discussion of the latest evidence for LDN in your specific condition
- Review of potential benefits, risks, and side effects
- Personalized dosing strategy (starting low and titrating slowly)
- Coordination with your pharmacy for compounded LDN
- Monitoring plan and follow-up schedule